Article

Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity

2021-06-07

Abstract excerpt

<h4>Summary</h4> A series of amyotrophic lateral sclerosis (ALS)-related proteins such as FUS, TDP-43 and hnRNPA1 has an ability to be liquid-liquid phase separation, and their disease-related mutations cause the transition of their responsible liquid droplets to aggregates. Missense mutations in SQSTM1/p62 , which have been identified throughout the gene, are associated with ALS, frontotemporal degeneration (FT...

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Literature Corpus work: 13d3d05f-c17f-5348-b9e2-2e5937287ebc
DOI: 10.1101/2021.06.07.447422

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