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Article

The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions.

Molecular biology of the cell - 1 Nov 2020

Owen Izzy, Rhoads Shannon, Yee Debra, Wyne Hala, Gery Kevin, Hannula Isabelle, Sundrum Meenakshi, Shewmaker Frank

Abstract excerpt

Fused in Sarcoma (FUS) is a ubiquitously expressed protein that can phase-separate from nucleoplasm and cytoplasm into distinct liquid-droplet structures. It is predominantly nuclear and most of its functions are related to RNA and DNA metabolism. Excessive persistence of FUS within cytoplasmic phase-separated assemblies is implicated in the diseases amyotrophic lateral sclerosis and frontotemporal dementia....

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Share to Cytoplasm
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Prions

Share to Protein Aggregation, Pathological

Share to Protein Processing, Post-Translational

Share to Proteomics

Share to RNA-Binding Protein FUS

Source

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Identifiers

PMID: 32877292
DOI: 10.1091/mbc.E20-05-0290
PMCID: PMC7851872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions.PMID 32877292Read ↗

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