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Article

A prime editor efficiently repaired human induced pluripotent stem cells with AR gene mutation (c.2710G > A; p. V904M).

Stem cell research - 1 Jun 2023

Sun Ruiqi, Cui Yiqiang, Liu Zhaode, Guo Jiayin, Zhang Xin, Zhu Pinmou, Sha Jiahao, Yang Xiaoyu, Yuan Yan

Abstract excerpt

Prime Editor (PE) is a precise genome manipulation technology based on the CRISPR-Cas9 system, while its application in human induced pluripotent stem cells (iPSCs) remains limited. Here, we established a repaired hiPS cell line (SKLRMi001-A-1) from hiPSCs with androgen receptor (AR) mutation (c.2710G > A; p.V904M). The repaired iPSC line expressed pluripotency markers, retained normal karyotype, showed the...

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Identifiers

PMID: 37148822
DOI: 10.1016/j.scr.2023.103102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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