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p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY

4 May 2023

Abstract excerpt

The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell cycle arrest, apoptosis and DNA repair. JMY is an actin nucleator and DNA damage-responsive protein whose sub-cellular localisation is responsive to stress and during DNA damage JMY undergoes nuclear accumulation. To gain an understanding of the wider role for...

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PMID: 37142657
DOI: 10.1038/s41418-023-01170-9

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