Article

The essential chaperone DNAJC17 activates HSP70 to coordinate RNA splicing and G2-M progression

2023-10-26

Abstract excerpt

Molecular chaperones including the heat-shock protein 70-kilodalton (HSP70) family and the J-domain containing protein (JDP) co-chaperones maintain homeostatic balance in eukaryotic cells through regulation of the proteome. The expansive JDP family helps direct specific HSP70 functions, and yet loss of single JDP-encoding genes is widely tolerated by mammalian cells, suggesting a high degree of redundancy. By cont...

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Literature Corpus work: 36662bc2-2c5f-5ef1-b9fe-f1d00ef2f581
DOI: 10.1101/2023.10.25.564066

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