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Article

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11.

Oncogene - 7 Jun 2012

Noll J E, Jeffery J, Al-Ejeh F, Kumar R, Khanna K K, Callen D F, Neilsen P M

Abstract excerpt

Mutations of p53 in cancer can result in a gain of function associated with tumour progression and metastasis. We show that inducible expression of several p53 'hotspot' mutants promote a range of centrosome abnormalities, including centrosome amplification, increased centrosome size and loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21986947
DOI: 10.1038/onc.2011.456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21986947-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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