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Article

Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation.

Genome medicine - 10 Mar 2021

Rao Shuquan, Yao Yao, Bauer Daniel E

Abstract excerpt

Genome-wide association studies (GWAS) have uncovered thousands of genetic variants that influence risk for human diseases and traits. Yet understanding the mechanisms by which these genetic variants, mainly noncoding, have an impact on associated diseases and traits remains a significant hurdle. In this review, we discuss emerging experimental approaches that are being applied for functional studies of causal...

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Share to Epigenesis, Genetic
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Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33691767
DOI: 10.1186/s13073-021-00857-3
PMCID: PMC7948363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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