The Role of TLR4, TNF-α and IL-1β in Type 2 Diabetes Mellitus Development within a North Indian Population.

doi:10.1111/ahg.12197

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The Role of TLR4, TNF-α and IL-1β in Type 2 Diabetes Mellitus Development within a North Indian Population.

Annals of human genetics - 1 Jul 2017

Doody Natalie E, Dowejko Monika M, Akam Elizabeth C, Cox Nick J, Bhatti Jasvinder S, Singh Puneetpal, Mastana Sarabjit S

Abstract excerpt

This study investigated the role of IL-1β-511 (rs16944), TLR4-896 (rs4986790) and TNF-α-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL-1β-511, TLR4-896 and TNF-α-308 loci. The C allele of IL-1β-511 was shown to increase T2DM susceptibility by...

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Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Association Studies

India

Interleukin-1beta

Logistic Models

Polymorphism, Genetic

Toll-Like Receptor 4

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 28620993
DOI: 10.1111/ahg.12197

Genes

TLR4
TNF

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