Article
Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2023
Ji Yuekai, Temprano-Sagrera Gerard, Holle Lori A, Bebo Allison, Brody Jennifer A, Le Ngoc-Quynh, Kangro Kadri, Brown Michael R, Martinez-Perez Angel, Sitlani Colleen M, Suchon Pierre, Kleber Marcus E, Emmert David B, Bilge Ozel Ayse, Dobson Dre'Von A, Tang Weihong, Llobet Dolors, Tracy Russell P, Deleuze Jean-François, Delgado Graciela E, Gögele Martin, Wiggins Kerri L, Souto Juan Carlos, Pankow James S, Taylor Kent D, Trégouët David-Alexandre, Moissl Angela P, Fuchsberger Christian, Rosendaal Frits R, Morrison Alanna C, Soria Jose Manuel, Cushman Mary, Morange Pierre-Emmanuel, März Winfried, Hicks Andrew A, Desch Karl C, Johnson Andrew D, de Vries Paul S, Wolberg Alisa S, Smith Nicholas L, Sabater-Lleal Maria
Abstract excerpt
BACKGROUND: Antithrombin, PC (protein C), and PS (protein S) are circulating natural anticoagulant proteins that regulate hemostasis and of which partial deficiencies are causes of venous thromboembolism. Previous genetic association studies involving antithrombin, PC, and PS were limited by modest sample sizes or by being restricted to candidate genes. In the setting of the Cohorts for Heart and Aging Research...
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