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Article

Physiological anticoagulant deficiencies: pathogenesis, diagnosis, and clinical implications.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2026

Mayger Katarzyna, Orlando Christelle, Hunt Beverley J

Abstract excerpt

Physiological anticoagulants are essential regulators of coagulation, and their deficiency shifts hemostasis toward a prothrombotic state, increasing the risk of venous thromboembolism. The main physiological anticoagulants, antithrombin (AT), protein C (PC), and protein S (PS), act via distinct mechanisms: AT directly inhibits active proteases, mainly thrombin and factor Xa, while PC deactivates activated...

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Source

Identifiers

PMID: 42362031
DOI: 10.1016/j.jtha.2026.06.020

Genes

PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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