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Article

Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study.

Circulation. Cardiovascular genetics - 1 Aug 2016

Solomon Terry, Smith Erin N, Matsui Hiroko, Braekkan Sigrid K, Wilsgaard Tom, Njølstad Inger, Mathiesen Ellisiv B, Hansen John-Bjarne, Frazer Kelly A

Abstract excerpt

BACKGROUND: Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated with diseases...

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Identifiers

PMID: 27329291
DOI: 10.1161/CIRCGENETICS.115.001327
PMCID: PMC4982757

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