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Article

Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.

British journal of haematology - 1 Apr 2012

Oudot-Mellakh Tiphaine, Cohen William, Germain Marine, Saut Noémie, Kallel Choumous, Zelenika Diana, Lathrop Mark, Trégouët David-Alexandre, Morange Pierre-Emmanuel

Abstract excerpt

Deficiencies of antithrombin (AT), protein C (PC) and protein S (PS) or an impaired PC anticoagulant pathway increase the risk of venous thrombosis (VT). By conducting a genome-wide association study (GWAS) on two independent samples of VT patients totalling 951 subjects typed for 472 173 single nucleotide polymorphisms (SNPs), we observed that common SNPs explain 21% and 27% of the genetic variance of plasma AT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22443383
DOI: 10.1111/j.1365-2141.2011.09025.x

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PROCR

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