Article
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program.
Circulation. Genomic and precision medicine - 1 Apr 2023
Seyerle Amanda A, Laurie Cecelia A, Coombes Brandon J, Jain Deepti, Conomos Matthew P, Brody Jennifer, Chen Ming-Huei, Gogarten Stephanie M, Beutel Kathleen M, Gupta Namrata, Heckbert Susan R, Jackson Rebecca D, Johnson Andrew D, Ko Darae, Manson JoAnn E, McKnight Barbara, Metcalf Ginger A, Morrison Alanna C, Reiner Alexander P, Sofer Tamar, Tang Weihong, Wiggins Kerri L, Boerwinkle Eric, de Andrade Mariza, Gabriel Stacey B, Gibbs Richard A, Laurie Cathy C, Psaty Bruce M, Vasan Ramachandran S, Rice Ken, Kooperberg Charles, Pankow James S, Smith Nicholas L, Pankratz Nathan
Abstract excerpt
BACKGROUND: Risk for venous thromboembolism has a strong genetic component. Whole genome sequencing from the TOPMed program (Trans-Omics for Precision Medicine) allowed us to look for new associations, particularly rare variants missed by standard genome-wide association studies. METHODS: The 3793 cases and 7834 controls (11.6% of cases were individuals of African, Hispanic/Latino, or Asian ancestry) were...
Topics
Join the communities discussing this publication.