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Article

Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2018

Olson N C, Raffield L M, Lange L A, Lange E M, Longstreth W T, Chauhan G, Debette S, Seshadri S, Reiner A P, Tracy R P

Abstract excerpt

ESSENTIALS: Essentials A fraction of coagulation factor VII circulates in blood as an activated protease (FVIIa). We evaluated FVIIa and FVIIa-antithrombin (FVIIa-AT) levels in the Cardiovascular Health Study. Polymorphisms in the F7 and PROCR loci were associated with FVIIa and FVIIa-AT levels. FVIIa may be an ischemic stroke risk factor in older adults and FVIIa-AT may assess mortality risk. SUMMARY: Background...

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Identifiers

PMID: 29112333
DOI: 10.1111/jth.13899
PMCID: PMC5760305

Genes

PROCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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