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Article

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

1 May 2023

Abstract excerpt

Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements, control of transposition in vivo remains poorly understood. MOV10, an RNA helicase, is an inhibitor of mobilization of retrotransposons and retroviruses in cell culture assays. Here...

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PMID: 37126510
DOI: 10.1371/journal.pgen.1010566

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