Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

Molecular cell - 22 May 2014

Gregersen Lea H, Schueler Markus, Munschauer Mathias, Mastrobuoni Guido, Chen Wei, Kempa Stefan, Dieterich Christoph, Landthaler Markus

Abstract excerpt

RNA helicases are important regulators of gene expression that act by remodeling RNA secondary structures and RNA-protein interactions. Here, we demonstrate that MOV10 has an ATP-dependent 5' to 3' in vitro RNA unwinding activity and determine the RNA-binding sites of MOV10 and its helicase mutants using PAR-CLIP. We find that MOV10 predominantly binds to 3' UTRs upstream of regions predicted to form local...

Topics

Join the communities discussing this publication.

3' Untranslated Regions
Amino Acid Motifs
Gene Knockdown Techniques
Nonsense Mediated mRNA Decay
Protein Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Source

Identifiers

PMID: 24726324
DOI: 10.1016/j.molcel.2014.03.017

Genes

MOV10
UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.PMID 24726324Read ↗

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in miceSemantic proximity Read ↗

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cellsSemantic proximity Read ↗

Dynamic RNA binding and unfolding by nonsense-mediated mRNA decay factor UPF2Semantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in miceSemantic proximity Read ↗

Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3BSemantic proximity Read ↗

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.Semantic proximity Read ↗

Modulation of UPF1 catalytic activity upon interaction of SARS-CoV-2 Nucleocapsid protein with factors involved in nonsense mediated-mRNA decaySemantic proximity Read ↗

UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.Semantic proximity Read ↗

The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation.Semantic proximity Read ↗

LARP4 Is an RNA-Binding Protein That Binds Nuclear-Encoded Mitochondrial mRNAs To Promote Mitochondrial FunctionSemantic proximity Read ↗

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.