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Article

Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition

23 Dec 2017

Abstract excerpt

Long interspersed nuclear element 1 is an autonomous non-long terminal repeat retrotransposon that comprises ∼17% of the human genome. Its spontaneous retrotransposition and the accumulation of heritable L1 insertions can potentially result in genome instability and sporadic disorders. Moloney leukemia virus 10 homolog (MOV10), a putative RNA helicase, has been implicated in inhibiting L1 replication, although...

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PMID: 29315404
DOI: 10.1093/nar/gkx1312

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