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Article

Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.

Nature communications - 6 Jul 2020

Kawabe Takeshi, Yi Jaeu, Kawajiri Akihisa, Hilligan Kerry, Fang Difeng, Ishii Naoto, Yamane Hidehiro, Zhu Jinfang, Jankovic Dragana, Kim Kwang Soon, Trinchieri Giorgio, Sher Alan

Abstract excerpt

CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions is still unclear. Here we...

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PMID: 32632165
DOI: 10.1038/s41467-020-17136-1
PMCID: PMC7338451

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