Article
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice.
Nature aging - 1 Dec 2021
Suda Masayoshi, Shimizu Ippei, Katsuumi Goro, Yoshida Yohko, Hayashi Yuka, Ikegami Ryutaro, Matsumoto Naomi, Yoshida Yutaka, Mikawa Ryuta, Katayama Akihiro, Wada Jun, Seki Masahide, Suzuki Yutaka, Iwama Atsushi, Nakagami Hironori, Nagasawa Ayako, Morishita Ryuichi, Sugimoto Masataka, Okuda Shujiro, Tsuchida Masanori, Ozaki Kazuyuki, Nakanishi-Matsui Mayumi, Minamino Tohru
Abstract excerpt
Elimination of senescent cells (senolysis) was recently reported to improve normal and pathological changes associated with aging in mice1,2. However, most senolytic agents inhibit antiapoptotic pathways3, raising the possibility of off-target effects in normal tissues. Identification of alternative senolytic approaches is therefore warranted. Here we identify glycoprotein nonmetastatic melanoma protein B (GPNMB)...
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