Article
A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse.
Experimental gerontology - 1 Apr 2023
Sugiyama Yuma, Harada Tanenobu, Kamei Yuka, Yasuda Tomoharu, Mashimo Tomoji, Nishikimi Akihiko, Maruyama Mitsuo
Abstract excerpt
Senescent cells were recently shown to play a role in aging-related malfunctions and pathologies. This consensus has been facilitated by evidence from senolytic model mice capable of eliminating senescent cells in tissues using well-characterized senescent markers, such as p16INK4a (hereafter p16). However, since the incomplete or artificial gene expression regulatory regions of manipulated marker genes affect...
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