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Reversing Immunosenescence with Senolytics to Enhance Tumor Immunotherapy

2024-10-15

Abstract excerpt

Recent advancements in cancer immunotherapy have improved patient outcomes, yet responses to immunotherapy remain moderate. We conducted a Phase II clinical trial ( NCT04718415 ) involving 51 cancer patients undergoing neoadjuvant chemoimmunotherapy and applied single-cell RNA and T/BCR sequencing on tumor and blood samples to elucidate the immune cell perturbations. Our findings associate poor response with reduc...

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Identifiers and source

Literature Corpus work
d973a810-96f7-5ca8-8d01-54d590a89c7f
DOI
10.1101/2024.10.14.24315428
Open publication

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Reversing Immunosenescence with Senolytics to Enhance Tumor ImmunotherapyDOI 10.1101/2024.10.14.24315428
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