PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

doi:10.1016/j.ccell.2018.06.007

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

Cancer cell - 9 Jul 2018

Georgilis Athena, Klotz Sabrina, Hanley Christopher J, Herranz Nicolas, Weirich Benedikt, Morancho Beatriz, Leote Ana Carolina, D'Artista Luana, Gallage Suchira, Seehawer Marco, Carroll Thomas, Dharmalingam Gopuraja, Wee Keng Boon, Mellone Marco, Pombo Joaquim, Heide Danijela, Guccione Ernesto, Arribas Joaquín, Barbosa-Morais Nuno L, Heikenwalder Mathias, Thomas Gareth J, Zender Lars, Gil Jesús

Abstract excerpt

Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target. Here, we describe an RNAi screen for SASP regulators. We identified 50 druggable targets whose knockdown suppresses the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Heterogeneous-Nuclear Ribonucleoproteins

Share to MCF-7 Cells

Share to Paracrine Communication

Share to Polypyrimidine Tract-Binding Protein

Share to Tumor Burden

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29990503
DOI: 10.1016/j.ccell.2018.06.007
PMCID: PMC6048363

Genes

PTBP1
EXOC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.PMID 29990503Read ↗

Senescent cells and their secretory phenotype as targets for cancer therapy.Semantic proximity Read ↗

Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging.Semantic proximity Read ↗

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related DiseasesSemantic proximity Read ↗

The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expressionSemantic proximity Read ↗

Exosomes are key regulators of non-cell autonomous communication in senescenceSemantic proximity Read ↗

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype.Semantic proximity Read ↗

Senescent Cells in Cancer Therapy: Friends or Foes?Semantic proximity Read ↗

Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathwaysSemantic proximity Read ↗

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses.Semantic proximity Read ↗

Targeting cellular senescence in cancer and aging: roles of p53 and its isoformsSemantic proximity Read ↗

A proteomic atlas of senescence-associated secretomes for aging biomarker development.Semantic proximity Read ↗

The senescence-associated secretory phenotype: the dark side of tumor suppression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.