Article
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
9 Mar 2015
Abstract excerpt
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of drugs termed senolytics, which selectively kill senescent cells. By transcript analysis, we...
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