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Article

Aurora B Inhibitors as Cancer Therapeutics

11 Apr 2023

Abstract excerpt

The Aurora kinases (A, B, and C) are a family of three isoform serine/threonine kinases that regulate mitosis and meiosis. The Chromosomal Passenger Complex (CPC), which contains Aurora B as an enzymatic component, plays a critical role in cell division. Aurora B in the CPC ensures faithful chromosome segregation and promotes the correct biorientation of chromosomes on the mitotic spindle. Aurora B overexpression...

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PMID: 37110619
DOI: 10.3390/molecules28083385

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