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Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A Literature Review

1 Apr 2023

Abstract excerpt

CD8+T cell exhaustion is a state of T cell dysfunction during chronic infection and tumor progression. Exhausted CD8+T cells are characterized by low effector function, high expression of inhibitory receptors, unique metabolic patterns, and altered transcriptional profiles. Recently, advances in understanding and interfering with the regulatory mechanisms associated with T cell exhaustion in tumor immunotherapy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37106742
DOI: 10.3390/biology12040541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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