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T cell exhaustion in cancer: Mechanisms and clinical implications

24 Dec 2017

Abstract excerpt

During chronic viral infection or cancer, the immune system usually induces a corresponding immune response against pathogens or cancer cells so as to prevent worsening disease. T cell exhaustion in which reduced and dysfunctional effector T cells lead to immune escape is one of the mechanisms that pathogens or cancer cells get rid of control from the immune system. In this review, we discuss some mechanisms...

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PMID: 29274296
DOI: 10.1002/jcb.26645

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