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Article

T‐cell exhaustion: characteristics, causes and conversion

23 Feb 2010

Abstract excerpt

T-cell exhaustion is characterized by the stepwise and progressive loss of T-cell functions and can culminate in the physical deletion of the responding cells. Exhaustion is well-defined during chronic lymphocytic choriomeningitis virus infection and commonly develops under conditions of antigen-persistence, which occur following many chronic infections that are of significant public health concern including...

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PMID: 20201977
DOI: 10.1111/j.1365-2567.2010.03255.x

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