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Exhausted T cells and epigenetic status

1 Jan 2020

Abstract excerpt

Exhausted T cells are a group of dysfunctional T cells, which are present in chronic infections or tumors. The most significant characteristics of exhausted T cells are attenuated effector cytotoxicity, reduced cytokine production, and upregulation of multiple inhibitory molecular receptors (e.g., PD-1, TIM-3, and LAG-3). The intracellular metabolic changes, altered expression of transcription factors, and a...

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PMID: 33299644
DOI: 10.20892/j.issn.2095-3941.2020.0338

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