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Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion

1 Jan 2020

Abstract excerpt

Exhaustion cripples T cell effector responses against metastatic cancers and chronic infections alike. There has been considerable interest in understanding the molecular and cellular mechanisms driving T cell exhaustion in human cancers fueled by the success of immunotherapy drugs especially the checkpoint receptor blockade (CRB) inhibitory antibodies that reverses T cell functional exhaustion. The current...

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PMID: 32363117
DOI: 10.1080/2162402x.2020.1747349

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