Article
Clinical implications of SRSF2 mutations in AML patients undergoing allogeneic stem cell transplantation.
American journal of hematology - 1 Oct 2021
Grimm Juliane, Jentzsch Madlen, Bill Marius, Backhaus Donata, Brauer Dominic, Küpper Johannes, Schulz Julia, Franke Georg-Nikolaus, Vucinic Vladan, Niederwieser Dietger, Platzbecker Uwe, Schwind Sebastian
Abstract excerpt
The SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial target. While SRSF2 mutations are enriched in secondary AML and associated with worse outcomes following chemotherapy consolidation, very little is known about the associated...
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