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Article

Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells.

Stem cells (Dayton, Ohio) - 1 Nov 2018

Bapat Aditi, Keita Nakia, Martelly William, Kang Paul, Seet Christopher, Jacobsen Jeffery R, Stoilov Peter, Hu Chengcheng, Crooks Gay M, Sharma Shalini

Abstract excerpt

Myeloid malignancies, including myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia, are characterized by abnormal proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs). Reports on analysis of bone marrow samples from patients have revealed a high incidence of mutations in splicing factors in early stem and progenitor cell clones, but the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30004607
DOI: 10.1002/stem.2885
PMCID: PMC6283046

Genes

SRSF2
U2AF1
CD34

Provenance

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Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells.PMID 30004607Read ↗

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