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Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC

3 Apr 2023

Abstract excerpt

Objectives: The exhausted CD8+T (Tex) cells are a unique cell population of activated T cells that emerges in response to persistent viral infection or tumor antigens. Tex cells showed the characteristics of aging cells, including weakened self-renewal ability, effector function inhibition, sustained high expression of inhibitory receptors including PD-1, TIGIT, TIM-3, and LAG-3, and always accompanied by...

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PMID: 37077914
DOI: 10.3389/fimmu.2023.1166052

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