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Article

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development.

Expert opinion on drug metabolism & toxicology - 1 Jun 2012

Lai Yurong, Varma Manthena, Feng Bo, Stephens Joel Clay, Kimoto Emi, El-Kattan Ayman, Ichikawa Katsuomi, Kikkawa Hironori, Ono Chiho, Suzuki Akiyuki, Suzuki Misaki, Yamamoto Yuichi, Tremaine Larry

Abstract excerpt

INTRODUCTION: Drug transporter proteins are expressed on the cell membrane, regulating substrate exposure in systemic circulation and/or peripheral tissues. Genetic polymorphism of drug transporter genes encoding these proteins could alter the functional activity and/or protein expression, having effects on absorption, distribution, metabolism and excretion (ADME), efficacy and adverse effects. AREAS COVERED: The...

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Identifiers

PMID: 22509796
DOI: 10.1517/17425255.2012.678048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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