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Article

Respective influence of beta-amyloid and APOE ε4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults.

Neurobiology of disease - 1 Jun 2023

de Flores Robin, Demeilliez-Servouin Solène, Kuhn Elizabeth, Chauveau Léa, Landeau Brigitte, Delcroix Nicolas, Gonneaud Julie, Vivien Denis, Chételat Gaël

Abstract excerpt

Medial temporal lobe (MTL) subregions are differentially affected in Alzheimer's disease (AD), with a specific involvement of the entorhinal cortex (ERC), perirhinal cortex and hippocampal cornu ammonis (CA)1. While amyloid (Aβ) and APOEε4 are respectively the first molecular change and the main genetic risk factor in AD, their links with MTL atrophy remain relatively unclear. Our aim was to uncover these effects...

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Identifiers

PMID: 37061167
DOI: 10.1016/j.nbd.2023.106127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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