Article

Downstream signaling of disease-associated mutations on GPR56/ADGRG1

2023-01-10

Abstract excerpt

GPR56/ADGRG1 is an adhesion GPCR and mutations on this receptor cause cortical malformation due to the over-migration of neural progenitor cells on the brain surface. At the pial surface, GPR56 interacts with collagen III, induces Rho dependent activation through Gα12/13 and inhibits the neuronal migration. In human glioma cells, GPR56 inhibits cell migration through Gαq/11 dependent Rho pathway. GPR56-tetraspanin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05262e84-be62-5fe2-b82d-b3607e256d0f
DOI: 10.22541/au.167338513.35935613/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Downstream signaling of disease-associated mutations on GPR56/ADGRG1DOI 10.22541/au.167338513.35935613/v1Read

Downstream signalling of the disease-associated mutations on GPR56/ADGRG1.Semantic proximity Read

GPR56: An adhesion GPCR involved in brain development, neurological disorders and cancer.Semantic proximity Read

Functions of G protein‐coupled receptor 56 in health and diseaseSemantic proximity Read

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.Semantic proximity Read

GPR56 interacts with extracellular matrix and regulates cancer progression.Semantic proximity Read

The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity.Semantic proximity Read

Structural basis for adhesion G protein-coupled receptor Gpr126 functionSemantic proximity Read

GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in GlioblastomaSemantic proximity Read

Orphan G protein–coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathwaySemantic proximity Read

GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cellsSemantic proximity Read

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.Semantic proximity Read

An Insight into GPCR and G-Proteins as Cancer DriversSemantic proximity Read