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Article

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.

Nature communications - 21 Jan 2015

Giera Stefanie, Deng Yiyu, Luo Rong, Ackerman Sarah D, Mogha Amit, Monk Kelly R, Ying Yanqin, Jeong Sung-Jin, Makinodan Manabu, Bialas Allison R, Chang Bernard S, Stevens Beth, Corfas Gabriel, Piao Xianhua

Abstract excerpt

Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Magnetic resonance imaging (MRI) of BFPP brains reveals myelination defects in addition to brain malformation. However, the cellular role of GPR56 in oligodendrocyte development remains unknown. Here, we demonstrate that loss of Gpr56 leads to...

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Identifiers

PMID: 25607655
DOI: 10.1038/ncomms7121
PMCID: PMC4302951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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