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Article

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.

PloS one - 1 Jan 2014

Luo Rong, Jeong Sung-Jin, Yang Annie, Wen Miaoyun, Saslowsky David E, Lencer Wayne I, Araç Demet, Piao Xianhua

Abstract excerpt

GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Despite the importance of GPR56 in brain development, where mutations cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP), the signaling mechanism(s) remain largely unknown. Like many other adhesion GPCRs, GPR56 is cleaved via a GPCR autoproteolysis-inducing (GAIN) domain into N- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24949629
DOI: 10.1371/journal.pone.0100043
PMCID: PMC4065004

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