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Article

Disease-associated mutations prevent GPR56-collagen III interaction.

PloS one - 1 Jan 2012

Luo Rong, Jin Zhaohui, Deng Yiyu, Strokes Natalie, Piao Xianhua

Abstract excerpt

GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Mutations in GPR56 cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Using the N-terminal fragment of GPR56 (GPR56(N)) as a probe, we have recently demonstrated that collagen III is the ligand of GPR56 in the developing brain. In this report, we discover a new functional domain in...

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Identifiers

PMID: 22238662
DOI: 10.1371/journal.pone.0029818
PMCID: PMC3251603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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