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Article

The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity.

The Journal of biological chemistry - 19 Aug 2011

Paavola Kevin J, Stephenson Jason R, Ritter Stefanie L, Alter Shawn P, Hall Randy A

Abstract excerpt

GPR56 is an adhesion G protein-coupled receptor that plays a key role in cortical development. Mutations to GPR56 in humans cause malformations of the cerebral cortex, but little is known about the normal function of the receptor. We found that the large N terminus (NT) of GPR56 is cleaved from the rest of the receptor during processing but remains non-covalently associated with the seven-transmembrane region of...

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Identifiers

PMID: 21708946
DOI: 10.1074/jbc.M111.247973
PMCID: PMC3190698

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