Article
Haptoglobin Hp2 Variant Promotes Premature Cardiovascular Death in Stroke Survivors.
Stroke - 1 Jun 2017
Ijäs Petra, Melkas Susanna, Saksi Jani, Jula Antti, Jauhiainen Matti, Oksala Niku, Pohjasvaara Tarja, Kaste Markku, Karhunen Pekka J, Lindsberg Perttu, Erkinjuntti Timo
Abstract excerpt
BACKGROUND AND PURPOSE: Haptoglobin (Hp) is an acute phase plasma protein protecting tissues from oxidative damage. It exists in 2 variant alleles (hp1/hp2) giving rise to 3 protein isoforms with different biochemical properties and efficiency to limit oxidative stress. We previously found that hp2 variant is associated with stroke risk in the patients with carotid stenosis and the risk of ischemic cardiovascular...
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