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Article

Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases.

PloS one - 1 Jan 2018

Tisato Veronica, Zuliani Giovanni, Vigliano Marco, Longo Giovanna, Franchini Eugenia, Secchiero Paola, Zauli Giorgio, Paraboschi Elvezia Maria, Vikram Singh Ajay, Serino Maria Luisa, Ortolani Beatrice, Zurlo Amedeo, Bosi Cristina, Greco Antonio, Seripa Davide, Asselta Rosanna, Gemmati Donato

Abstract excerpt

Cognitive impairments of different aetiology share alterations in iron and lipid homeostasis with mutual relationships. Since iron and cholesterol accumulation impact on neurodegenerative disease, the associated gene variants are appealing candidate targets for risk and disease progression assessment. In this light, we explored the role of common single nucleotide polymorphisms (SNPs) in the main iron homeostasis...

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Source

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Identifiers

PMID: 29518107
DOI: 10.1371/journal.pone.0193867
PMCID: PMC5843269

Genes

HFE
APOE
HAMP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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