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Article

Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.

ACS chemical neuroscience - 17 Sept 2014

Spagnuolo Maria Stefania, Maresca Bernardetta, La Marca Valeria, Carrizzo Albino, Veronesi Carlo, Cupidi Chiara, Piccoli Tommaso, Maletta Raffaele Giovanni, Bruni Amalia Cecilia, Abrescia Paolo, Cigliano Luisa

Abstract excerpt

Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25058565
DOI: 10.1021/cn500099f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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