Article
TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia.
PloS one - 1 Jan 2015
Mori Yoko, Yoshino Yuta, Ochi Shinichiro, Yamazaki Kiyohiro, Kawabe Kentaro, Abe Masao, Kitano Tomoji, Ozaki Yuki, Yoshida Taku, Numata Shusuke, Mori Takaaki, Iga Junichi, Kuroda Norio, Ohmori Tetsuro, Ueno Shu-Ichi
Abstract excerpt
UNLABELLED: TREM2 and TYROBP are causal genes for Nasu-Hakola disease (NHD), a rare autosomal recessive disease characterized by bone lesions and early-onset progressive dementia. TREM2 forms a receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages and dendritic cells, and the functional polymorphism of TREM2 is reported to be associated with neurodegenerative...
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