Article
Label-Free Cell Phenotypic Assays for Assessing Drug Polypharmacology.
Current pharmaceutical design - 1 Jan 2016
Wang Jixia, Zhang Xiuli, Fang Ye, Liang Xinmiao
Abstract excerpt
BACKGROUND: Most drugs exert their biological and physiological effects via binding to protein targets. Although drugs are traditionally optimized against a single protein, most marketed drugs exhibit clinically relevant polypharmacology - the activity of drugs at multiple targets. The wide-spread presence of polypharmacology makes it challenging to assess the mechanisms of action of multi-target drugs. METHODS:...
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