Back to search

Article

Improving Phenotypic Measurements in High-Content Imaging Screens

2017-07-10

Abstract excerpt

Image-based screening is a powerful technique to reveal how chemical, genetic, and environmental perturbations affect cellular state. Its potential is restricted by the current analysis algorithms that target a small number of cellular phenotypes and rely on expert-engineered image features. Newer algorithms that learn how to represent an image are limited by the small amount of labeled data for ground-truth, a co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b95433e8-f48b-5d06-92ff-777a117a714b
DOI
10.1101/161422
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Improving Phenotypic Measurements in High-Content Imaging ScreensDOI 10.1101/161422
Unsupervised phenotypic analysis of cellular images with multi-scale convolutional neural networksSemantic proximity
MORE IS DIFFERENT: DRUG PROPERTY ANALYSIS ON CELLULAR HIGH-CONTENT IMAGES USING DEEP LEARNINGSemantic proximity
Image-based high-content screening in drug discovery.Semantic proximity
Self-supervised deep learning uncovers the semantic landscape of drug-induced latent mitochondrial phenotypesSemantic proximity
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.Semantic proximity
A Highly-Efficient, Scalable Pipeline for Fixed Feature Extraction from Large-Scale High-Content Imaging ScreensSemantic proximity
Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines.Semantic proximity
Deep learning in image-based phenotypic drug discovery.Semantic proximity
Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis.Semantic proximity
Image-based multivariate profiling of drug responses from single cells.Semantic proximity
Image-based chemical screening.Semantic proximity
Predicting cell health phenotypes using image-based morphology profiling.Semantic proximity
Select a neighboring publication to make it the new centre.