Article
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.
Journal of biomolecular screening - 1 Dec 2013
Ljosa Vebjorn, Caie Peter D, Ter Horst Rob, Sokolnicki Katherine L, Jenkins Emma L, Daya Sandeep, Roberts Mark E, Jones Thouis R, Singh Shantanu, Genovesio Auguste, Clemons Paul A, Carragher Neil O, Carpenter Anne E
Abstract excerpt
Quantitative microscopy has proven a versatile and powerful phenotypic screening technique. Recently, image-based profiling has shown promise as a means for broadly characterizing molecules' effects on cells in several drug-discovery applications, including target-agnostic screening and predicting a compound's mechanism of action (MOA). Several profiling methods have been proposed, but little is known about their...
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