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Article

Genome-wide association testing in malaria studies in the presence of overdominance.

Malaria journal - 10 Apr 2023

Akoth Morine, Odhiambo John, Omolo Bernard

Abstract excerpt

BACKGROUND: In human genetics, heterozygote advantage (heterosis) has been detected in studies that focused on specific genes but not in genome-wide association studies (GWAS). For example, heterosis is believed to confer resistance to certain strains of malaria in patients heterozygous for the sickle-cell gene, haemoglobin S (HbS). Yet the power of allelic tests can be substantially diminished by heterosis....

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Identifiers

PMID: 37038187
DOI: 10.1186/s12936-023-04533-2
PMCID: PMC10084622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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