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Article

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.

eLife - 6 Jul 2021

Watson James A, Ndila Carolyne M, Uyoga Sophie, Macharia Alexander, Nyutu Gideon, Mohammed Shebe, Ngetsa Caroline, Mturi Neema, Peshu Norbert, Tsofa Benjamin, Rockett Kirk, Leopold Stije, Kingston Hugh, George Elizabeth C, Maitland Kathryn, Day Nicholas Pj, Dondorp Arjen M, Bejon Philip, Williams Thomas N, Holmes Chris C, White Nicholas J

Abstract excerpt

Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria, but phenotypic imprecision compromises discovered associations. In areas of high malaria transmission, the diagnosis of severe malaria in young children and, in...

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Identifiers

PMID: 34225842
DOI: 10.7554/eLife.69698
PMCID: PMC8315799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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