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Article

Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy.

Trends in parasitology - 1 Apr 2022

Ebel Emily R, Uricchio Lawrence H, Petrov Dmitri A, Egan Elizabeth S

Abstract excerpt

The malaria hypothesis predicts local, balancing selection of deleterious alleles that confer strong protection from malaria. Three protective variants, recently discovered in red cell genes, are indeed more common in African than European populations. Still, up to 89% of the heritability of severe malaria is attributed to many genome-wide loci with individually small effects. Recent analyses of hundreds of...

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Identifiers

PMID: 35065882
DOI: 10.1016/j.pt.2021.12.007
PMCID: PMC8916997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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