Article

Genome-wide association testing in malaria studies in the presence of overdominance

2022-07-26

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: In human genetics, heterozygote advantage (heterosis) has been detected in studies that focused on specific genes but not in genome-wide association studies (GWAS). For example, heterosis is believed to confer resistance to certain strains of malaria in patients heterozygous for the sickle-cell gene, <italic>HbS</italic>. Yet the power of allelic tests can be su...

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Literature Corpus work: b68a2c9e-57a1-5b54-8b2c-daa3c04260ac
DOI: 10.21203/rs.3.rs-1897783/v1

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